The short answer:
Omeprazole is commonly prescribed before breakfast on an empty stomach as food could decrease its absorption and thus attenuate its effectiveness. Also, drinking milk with omeprazole may affect its absorption. Therefore, it is better to wait for 30-60 minutes to drink milk after taking omeprazole.
- The absorption of orally administered omeprazole is strongly affected by the foods you ingest.
- Omeprazole is best to be taken in the morning before breakfast.
- Drinking milk with omeprazole could decrease its absorption and thus, attenuate its effectiveness.
- It is better to wait 30-60 minutes to drink milk after taking omeprazole.
- Drinking milk could itself help in relief the heartburn and symptoms of hyperacidity. however, its fat content may increase acid secretion. Therefore, drinking low-fat milk is preferred especially for those with symptoms of hyperacidity.
- Not only milk but also milk added to coffee or tea could decrease drug absorption.
Why can’t you take omeprazole with milk?
It is well known that drug-food interactions can strongly influence the safety and efficacy of drugs. The interactions of milk with the administered drugs are generally classified as pharmacokinetic interactions. This means milk could strongly affect the absorption and excretion of drugs. Sometimes these interactions could lead to the failure of treatments.
In addition, omeprazole similar to other proton pump inhibitors (PPIs), is a weak basic drug that is activated in an acidic medium. Drinking milk may help in neutralizing the acidic medium in the stomach and this could disrupt the absorption of omeprazole.
Therefore, it is better to avoid drinking milk with omeprazole and you have to wait at least 1 hour after taking omeprazole to drink milk safely.
A previous study showed that milk could decrease the absorption of omeprazole and thus decrease its bioavailability.
Drinking milk and also Fizzy drinks with omeprazole may negatively affect the absorption of omeprazole.
How soon can I drink milk after taking omeprazole?
Milk is a healthy beverage that is daily consumed worldwide by billions of people. It contains essential proteins, vitamins, and minerals such as calcium and phosphorus. However, as it could strongly affect the absorption of omeprazole and thus decrease its activity, it is better to wait for 30-60 minutes after taking omeprazole to drink milk safely.
Foods to avoid when using omeprazole.
Certain foods and drinks could aggravate your symptoms of excess acid, heartburn, or ulcers. So, you have to avoid such foods and drinks including the following (Ref).
- Acidic foods and drinks: These include lemon, oranges, apples, grapefruits, tomatoes, energy drinks, Coca-Cola, fruit juices.
- Fatty foods such as Pizza, and fried chicken. Fatty foods could slow down the digestive system leading to heartburn and indigestion.
- Spicey foods such as onion, garlic, peppermint containing foods.
- Caffeinated drinks (i.e. coffee and soda)
- Red and processed meats
- Sugary foods
- White wine and beer: they are reported to cause gastroesophageal reflux and thus decrease the benefits of omeprazole.
Which drug should not be given with milk?
A common question that is usually asked by many patients is whether or not to take medications and drink milk concurrently. The answer to this question simply depends on the components of your medications. Some medications are restricted to be taken with milk; others are ok.
The reason why some medications are not allowed with milk is the possible interactions of milk components, especially calcium, with components in your medications. In such conditions, not only milk but also other dairy products such as yogurt, cottage cheese, and buttermilk are not allowed to be taken with such medications.
Therefore, drinking milk is not only interacting with omeprazole but also, it is reported to interact with a wide range of medications. This type of interaction is commonly known as food-drug interaction. Such interactions could affect the safety and efficacy of concurrently administered medications.
Here is a list of some of the drugs that are reported to interact with milk:
- Certain antibiotics such as tetracycline that could bind with calcium in milk forming an insoluble complex (Ref).
- The fluoroquinolones (such as ciprofloxacin and levofloxacin) may be rendered ineffective when taken at the same time with milk.
- Antitumor agents such as mercaptopurine which deactivated by xanthine oxidase. Cow’s milk is known to contain a high level of xanthine oxidase. Therefore, most patients should avoid taking mercaptopurine and drinking milk (Ref).
- Thyroid medications such as levothyroxine. A study showed that concurrent cow’s milk ingestion with levothyroxine could reduce its absorption (Ref).
- Iron supplements: Drinking milk is reported to decrease the absorption of concurrently administered iron supplements. Milk could interfere with iron absorption in your stomach forming a complex that can’t be absorbed.
- Antiarrhythmic drugs such as sotalol: milk was reported to interact with Sotalol decreasing its absorption (Ref).
- Antiepileptic drugs such as Phenytoin: a study showed that the administration of phenytoin with milk reduced the amount absorbed of phenytoin to its half in healthy adults (Ref).
- Other medications include nonsteroidal anti-inflammatory drugs, digitalis, amiloride, spironolactone, propranolol, and ranitidine.
The above-mentioned medications are not all medications with possible interactions with milk. So, we must check the leaflet or ask your doctor about the possible interaction of your drug and milk or other dairy products.
As a general rule, the administration of milk or other dairy products should be separated from the interacting drugs by at least 2-4 hours.
1. Is milk good for gastritis and heartburn?
Milk has its advantages and disadvantages when it is used to relieve heartburn. Milk may act as a neutralizing buffer that helps in the relief of heartburn symptoms. Also, milk is assumed to coat the throat and stomach, relieving heartburn symptoms. However, the fat content in milk could trigger acid secretions and thus could worsen the condition.
Moreover, the fat content in milk takes a longer time to be digested compared with proteins and carbohydrates. This may delay stomach emptying and this is a common feature among people suffering from heartburn.
The delayed stomach emptying time caused by fat content in milk has been associated with prolonged esophageal exposure to gastric acids and this could worsen your heartburn symptoms (Ref).
Consequently, you can safely drink low-fat milk with less risk of aggravating the heartburn symptom.
2. Does coffee with milk or tea with milk affect drug absorption?
Not only free milk but also milk added to coffee or tea was found to affect the absorption of concurrently administered drugs.
A previous study investigated the effect of milk added to coffee or black tea on the bioavailability of tetracycline in healthy individuals. Results showed that even a small volume of milk containing a small quantity of calcium added to coffee or black tea impaired the absorption of the tetracycline,
The authors attributed this effect to the calcium ion content in milk (even a small amount). Therefore, the presence of this metal ion should be carefully controlled in order to avoid decreasing the available tetracycline.