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Why does omeprazole cause joint pain?

Joint pain is a rare but serious side effect of omeprazole due to subacute cutaneous lupus erythematosus which is is commonly resolved a few days after stopping omeprazole administration.

Can I take omeprazole at night?

Omeprazole is commonly prescribed once daily. It is better to be taken at the morning before breakfast. Read more about administration of omeprazole